Article
Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients.
The Journal of allergy and clinical immunology - 1 Aug 2013
Li Xingnan, Hawkins Gregory A, Ampleford Elizabeth J, Moore Wendy C, Li Huashi, Hastie Annette T, Howard Timothy D, Boushey Homer A, Busse William W, Calhoun William J, Castro Mario, Erzurum Serpil C, Israel Elliot, Lemanske Robert F, Szefler Stanley J, Wasserman Stephen I, Wenzel Sally E, Peters Stephen P, Meyers Deborah A, Bleecker Eugene R
Abstract excerpt
BACKGROUND: Recent meta-analyses of genome-wide association studies in general populations of European descent have identified 28 loci for lung function. OBJECTIVE: We sought to identify novel lung function loci specifically for asthma and to confirm lung function loci identified in general populations. METHODS: Genome-wide association studies of lung function (percent predicted FEV1 [ppFEV1], percent predicted...
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