Article
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.
Nature communications - 4 Dec 2015
Soler Artigas María, Wain Louise V, Miller Suzanne, Kheirallah Abdul Kader, Huffman Jennifer E, Ntalla Ioanna, Shrine Nick, Obeidat Ma'en, Trochet Holly, McArdle Wendy L, Alves Alexessander Couto, Hui Jennie, Zhao Jing Hua, Joshi Peter K, Teumer Alexander, Albrecht Eva, Imboden Medea, Rawal Rajesh, Lopez Lorna M, Marten Jonathan, Enroth Stefan, Surakka Ida, Polasek Ozren, Lyytikäinen Leo-Pekka, Granell Raquel, Hysi Pirro G, Flexeder Claudia, Mahajan Anubha, Beilby John, Bossé Yohan, Brandsma Corry-Anke, Campbell Harry, Gieger Christian, Gläser Sven, González Juan R, Grallert Harald, Hammond Chris J, Harris Sarah E, Hartikainen Anna-Liisa, Heliövaara Markku, Henderson John, Hocking Lynne, Horikoshi Momoko, Hutri-Kähönen Nina, Ingelsson Erik, Johansson Åsa, Kemp John P, Kolcic Ivana, Kumar Ashish, Lind Lars, Melén Erik, Musk Arthur W, Navarro Pau, Nickle David C, Padmanabhan Sandosh, Raitakari Olli T, Ried Janina S, Ripatti Samuli, Schulz Holger, Scott Robert A, Sin Don D, Starr John M, Viñuela Ana, Völzke Henry, Wild Sarah H, Wright Alan F, Zemunik Tatijana, Jarvis Deborah L, Spector Tim D, Evans David M, Lehtimäki Terho, Vitart Veronique, Kähönen Mika, Gyllensten Ulf, Rudan Igor, Deary Ian J, Karrasch Stefan, Probst-Hensch Nicole M, Heinrich Joachim, Stubbe Beate, Wilson James F, Wareham Nicholas J, James Alan L, Morris Andrew P, Jarvelin Marjo-Riitta, Hayward Caroline, Sayers Ian, Strachan David P, Hall Ian P, Tobin Martin D
Abstract excerpt
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA,...
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