Combined effects of fibrinogen genetic variability on atherosclerosis in patients with or without stable angina pectoris: focus on the coagulation cascade and endothelial function.

doi:10.1016/j.ijcard.2013.07.162

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Article

Combined effects of fibrinogen genetic variability on atherosclerosis in patients with or without stable angina pectoris: focus on the coagulation cascade and endothelial function.

International journal of cardiology - 12 Oct 2013

Papageorgiou Nikolaos, Tousoulis Dimitris, Miliou Antigoni, Hatzis George, Kozanitou Maria, Androulakis Emmanuel, Charakida Marietta, Antonopoulos Alexios, Antoniades Charalambos, Briasoulis Alexandros, Giolis Anastasios, Bouras George, Pallantza Zoi, Stefanadis Christodoulos

Abstract excerpt

BACKGROUND: Fibrinogen is a coagulation/inflammatory biomarker strongly associated with atherogenesis. Data have reported that the genetic variability on fibrinogen chains may affect the atherosclerotic process and the risk of coronary artery disease (CAD). We examined the combined effects of the G455A and the G58A fibrinogen genetic polymorphisms on prothrombotic profile, endothelial function and the risk of CAD...

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PMID: 23931975
DOI: 10.1016/j.ijcard.2013.07.162

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