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Article

Influence of PPARA, RXRA, NR1I2 and NR1I3 gene polymorphisms on the lipid-lowering efficacy and safety of statin therapy.

Arquivos brasileiros de endocrinologia e metabologia - 1 Oct 2013

Lima Luciana Otero, Bruxel Estela Maria, Hutz Mara Helena, Van der Sand Cézar Roberto, Van der Sand Luiz Carlos, Ferreira Maria Elvira Wagner, Pires Renan Canibal, Fiegenbaum Marilu, Almeida Silvana

Abstract excerpt

OBJECTIVE: The aim of the present study was investigate the association between six genetic variants in the nuclear receptor genes PPARA, RXRA, NR1I2 and NR1I3 and the lipid-lowering efficacy and safety of statin therapy. SUBJECTS AND METHODS: The study was carried out on 240 Brazilian hypercholesterolemic patients on simvastatin and atorvastatin therapy. The polymorphisms were analyzed by PCR-based methods....

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Source

Identifiers

PMID: 24232815
DOI: 10.1590/s0004-27302013000700003

Genes

PPARA
RXRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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