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Article

A role for IRF4 in the development of CLL.

Blood - 17 Oct 2013

Shukla Vipul, Ma Shibin, Hardy Richard R, Joshi Shantaram S, Lu Runqing

Abstract excerpt

Interferon regulatory factor 4 (IRF4) is a critical transcriptional regulator of B-cell development and function. A recent genome-wide single-nucleotide polymorphism (SNP) association study identified IRF4 as a major susceptibility gene in chronic lymphocytic leukemia (CLL). Although the SNPs located in the IRF4 gene were linked to a downregulation of IRF4 in CLL patients, whether a low level of IRF4 is critical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23926303
DOI: 10.1182/blood-2013-03-492769
PMCID: PMC3798999

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