Article
Investigating the role of pneumococcal neuraminidase A activity in isolates from pneumococcal haemolytic uraemic syndrome.
Journal of medical microbiology - 1 Nov 2013
Smith Andrew, Johnston Calum, Inverarity Donald, Slack Mary, K Paterson Gavin, Diggle Mathew, Mitchell Timothy
Abstract excerpt
Streptococcus pneumoniae diseases are a rare but increasingly recognized trigger of atypical haemolytic uraemic syndrome (HUS) in young children and associated with a higher mortality rate than diarrhoea-associated HUS. This study aimed to determine the importance of neuraminidase A (NanA) and genomic diversity in the pathogenesis of pneumococcal HUS (pHUS). We investigated the nanA gene sequence, gene...
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