Article
The role of complement in Streptococcus pneumoniae-associated haemolytic uraemic syndrome.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Sept 2013
Szilágyi Agnes, Kiss Nóra, Bereczki Csaba, Tálosi Gyula, Rácz Katalin, Túri Sándor, Györke Zsuzsa, Simon Edina, Horváth Eszter, Kelen Kata, Reusz György S, Szabó Attila J, Tulassay Tivadar, Prohászka Zoltán
Abstract excerpt
BACKGROUND: Atypical forms of haemolytic uraemic syndrome (aHUS) include HUS caused by defects in the regulation of alternative complement pathway and HUS linked to neuraminidase-producing pathogens, such as Streptococcus pneumoniae. Increasing data support a pathogenic role of neuraminidase in the development of S. pneumoniae-associated haemolytic uraemic syndrome (SP-HUS), but the role of complement has never...
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