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Article

The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion

17 Aug 2009

Abstract excerpt

In humans, Streptococcus pneumoniae (SPN) is the leading cause of bacterial meningitis, a disease with high attributable mortality and frequent permanent neurological sequelae. The molecular mechanisms underlying the central nervous system tropism of SPN are incompletely understood, but include a primary interaction of the pathogen with the blood-brain barrier (BBB) endothelium. All SPN strains possess a gene...

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PMID: 19687228
DOI: 10.1084/jem.20090386

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