Article
Differential effects of familial parkinson mutations in LRRK2 revealed by a systematic analysis of autophosphorylation.
Biochemistry - 3 Sept 2013
Kamikawaji Shogo, Ito Genta, Sano Tomoko, Iwatsubo Takeshi
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified in pedigrees of autosomal-dominant familial Parkinson's disease (PARK8). It has been shown that the kinase activity of LRRK2 is required for its neuronal toxicity, although how familial Parkinson mutations affect the...
Topics
- Chromatography, Thin Layer
- HEK293 Cells
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mutation
- Parkinson Disease
- Peptide Mapping
- Phosphopeptides
- Phosphorylation
- Protein Serine-Threonine Kinases
- Threonine