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Article

Genetic variants in epidermal growth factor receptor pathway genes and risk of esophageal squamous cell carcinoma and gastric cancer in a Chinese population.

PloS one - 1 Jan 2013

Li Wen-Qing, Hu Nan, Wang Zhaoming, Yu Kai, Su Hua, Wang Lemin, Wang Chaoyu, Chanock Stephen J, Burdett Laurie, Ding Ti, Qiao You-Lin, Fan Jin-Hu, Wang Yuan, Xu Yi, Giffen Carol, Xiong Xiaoqin, Murphy Gwen, Tucker Margaret A, Dawsey Sanford M, Freedman Neal D, Abnet Christian C, Goldstein Alisa M, Taylor Philip R

Abstract excerpt

The epidermal growth factor receptor (EGFR) signaling pathway regulates cell proliferation, differentiation, and survival, and is frequently dysregulated in esophageal and gastric cancers. Few studies have comprehensively examined the association between germline genetic variants in the EGFR pathway and risk of esophageal and gastric cancers. Based on a genome-wide association study in a Han Chinese population,...

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Source

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Identifiers

PMID: 23874846
DOI: 10.1371/journal.pone.0068999
PMCID: PMC3715462

Genes

EGFR
GNAI3
CHRNE
FYN
ITCH
MAPK8
PAK4
PLCG2
PRLR
TLN1
WASL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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