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Genetic variants in Ras/Raf/MEK/ERK pathway are associated with gastric cancer risk in Chinese Han population.

Archives of toxicology - 1 Aug 2020

Wang Xiaowei, Wu Xu, Xin Junyi, Li Shuwei, Zheng Rui, Guan Dan, Gong Weida, Zhao Qinghong, Wang Meilin, Chu Haiyan, Du Mulong, Tao Guoquan, Zhang Haiyan, Zhang Zhengdong

Abstract excerpt

The dysregulation of Ras/Raf/MEK/ERK pathway governs occurrence and progression of cancers. In previous studies, genome-wide association studies (GWAS) have identified multiple gene loci related to gastric cancer. However, a great many genetic loci have been missed due to multiple statistical comparisons of GWAS. In this study, Multi-marker Analysis of GenoMic Annotation (MAGMA) was applied to analyze genes in...

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PMID: 32524153
DOI: 10.1007/s00204-020-02771-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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