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Article

Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain.

Archives of general psychiatry - 1 Sept 2012

Malhotra Anil K, Correll Christoph U, Chowdhury Nabilah I, Müller Daniel J, Gregersen Peter K, Lee Annette T, Tiwari Arun K, Kane John M, Fleischhacker W Wolfgang, Kahn Rene S, Ophoff Roel A, Meltzer Herbert Y, Lencz Todd, Kennedy James L

Abstract excerpt

CONTEXT: Second-generation antipsychotics (SGAs) are increasingly used in the treatment of many psychotic and nonpsychotic disorders. Unfortunately, SGAs are often associated with substantial weight gain, with no means to predict which patients are at greatest risk. OBJECTIVE: To identify single-nucleotide polymorphisms associated with antipsychotic drug–induced weight gain. DESIGN: Pharmacogenetic association...

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Share to Antipsychotic Agents
Share to Chromosomes, Human, Pair 18

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Melanocortin, Type 4

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Source

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Identifiers

PMID: 22566560
DOI: 10.1001/archgenpsychiatry.2012.191
PMCID: PMC4166499

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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