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Evolutionary history of the poly(ADP-ribose) polymerase gene family in eukaryotes

13 Oct 2010

Abstract excerpt

BACKGROUND: The poly(ADP-ribose) polymerase (PARP) superfamily was originally identified as enzymes that catalyze the attachment of ADP-ribose subunits to target proteins using NAD+ as a substrate. The family is characterized by the catalytic site, termed the PARP signature. While these proteins can be found in a range of eukaryotes, they have been best studied in mammals. In these organisms, PARPs have key...

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PMID: 20942953
DOI: 10.1186/1471-2148-10-308

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