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Article

Shaping the murine macrophage phenotype: IL-4 and cyclic AMP synergistically activate the arginase I promoter.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2013

Sheldon Kathryn E, Shandilya Harish, Kepka-Lenhart Diane, Poljakovic Mirjana, Ghosh Arundhati, Morris Sidney M

Abstract excerpt

Arginase I is a marker of murine M2 macrophages and is highly expressed in many inflammatory diseases. The basis for high arginase I expression in macrophages in vivo is incompletely understood but likely reflects integrated responses to combinations of stimuli. Our objective was to elucidate mechanisms involved in modulating arginase I induction by IL-4, the prototypical activator of M2 macrophages. IL-4 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23913966
DOI: 10.4049/jimmunol.1202102
PMCID: PMC3829606

Genes

STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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