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Article

A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase.

The Journal of biological chemistry - 11 Oct 2013

Zhang Sufang, Zhao Hong, Darzynkiewicz Zbiegniew, Zhou Pengbo, Zhang Zhongtao, Lee Ernest Y C, Lee Marietta Y W T

Abstract excerpt

DNA polymerase δ (Pol δ4) is a heterotetrameric enzyme, whose p12 subunit is degraded in response to DNA damage, leaving behind a trimer (Pol δ3) with altered enzymatic characteristics that participate in gap filling during DNA repair. We demonstrate that CRL4(Cdt2), a key regulator of cell cycle progression that targets replication licensing factors, also targets the p12 subunit of Pol δ4 in response to DNA...

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PMID: 23913683
DOI: 10.1074/jbc.M113.490466
PMCID: PMC3795253

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