Article
Novel vacuolar H+-ATPase complexes resulting from overproduction of Vma5p and Vma13p.
The Journal of biological chemistry - 25 Jan 2002
Keenan Curtis Kelly, Kane Patricia M
Abstract excerpt
The vacuolar H(+)-ATPase (V-ATPase) is a multisubunit complex composed of two sectors: V(1), a peripheral membrane sector responsible for ATP hydrolysis, and V(0), an integral membrane sector that forms a proton pore. Vma5p and Vma13p are V(1) sector subunits that have been implicated in the structural and functional coupling of the V-ATPase. Cells overexpressing Vma5p and Vma13p demonstrate a classic Vma(-)...
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