Article
Surveillance for sulfadoxine-pyrimethamine resistant malaria parasites in the Lake and Southern Zones, Tanzania, using pooling and next-generation sequencing.
Malaria journal - 5 Jun 2017
Ngondi Jeremiah M, Ishengoma Deus S, Doctor Stephanie M, Thwai Kyaw L, Keeler Corinna, Mkude Sigsbert, Munishi Oresto M, Willilo Ritha A, Lalji Shabbir, Kaspar Naomi, Kitojo Chonge, Paxton Lynn A, Hathaway Nicholas J, Bailey Jeffrey A, Juliano Jonathan J, Meshnick Steven R, Gutman Julie
Abstract excerpt
BACKGROUND: Malaria in pregnancy (MiP) remains a major public health challenge in areas of high malaria transmission. Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended to prevent the adverse consequences of MiP. The effectiveness of SP for IPTp may be reduced in areas where the dhps581 mutation (a key marker of high level SP resistance) is found; this...
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