Testosterone Perturbs Systemic Iron Balance Through Activation of Epidermal Growth Factor Receptor Signaling in the Liver and Repression of Hepcidin

Abstract excerpt

UNLABELLED: Gender-related disparities in the regulation of iron metabolism may contribute to the differences exhibited by men and women in the progression of chronic liver diseases associated with reduced hepcidin expression, e.g., chronic hepatitis C, alcoholic liver disease, or hereditary hemochromatosis. However, their mechanisms remain poorly understood. In this study we took advantage of the major...

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