Article

Estrogen Receptor 1 Signaling in Hepatic Stellate Cells Designates Resistance to Liver Fibrosis

2024-10-14

Abstract excerpt

The prevalence and severity of liver fibrosis appear higher in men than in premenopausal women, while postmenopausal women exhibit the worsened disease. However, the pathophysiological mechanism underlying such clinical observations remains incompletely understood. Here, we show that sex hormone depletion in adult female mice exaggerates the model of liver fibrosis, while estradiol replacement in castrated male mi...

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Literature Corpus work: c21394ac-667f-51f3-ae05-8a7466bb4b09
DOI: 10.1101/2024.10.10.617541

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