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Article

Differences in hepatocellular iron metabolism underlie sexual dimorphism in hepatocyte ferroptosis

17 Sept 2023

Abstract excerpt

Males show higher incidence and severity than females in hepatic injury and many liver diseases, but the mechanisms are not well understood. Ferroptosis, an iron-mediated lipid peroxidation-dependent death, plays an important role in the pathogenesis of liver diseases. We determined whether hepatocyte ferroptosis displays gender difference, accounting for sexual dimorphism in liver diseases. Compared to female...

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PMID: 37741044
DOI: 10.1016/j.redox.2023.102892

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