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Article

Effect of Erythropoietin, Iron Deficiency and Iron Overload on Liver Matriptase-2 (TMPRSS6) Protein Content in Mice and Rats.

PloS one - 1 Jan 2016

Frýdlová Jana, Přikryl Petr, Truksa Jaroslav, Falke Lucas L, Du Xin, Gurieva Iuliia, Vokurka Martin, Krijt Jan

Abstract excerpt

Matriptase-2 (TMPRSS6) is an important negative regulator of hepcidin expression; however, the effects of iron overload or accelerated erythropoiesis on liver TMPRSS6 protein content in vivo are largely unknown. We determined TMPRSS6 protein content in plasma membrane-enriched fractions of liver homogenates by immunoblotting, using a commercial antibody raised against the catalytic domain of TMPRSS6. Plasma...

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Identifiers

PMID: 26845567
DOI: 10.1371/journal.pone.0148540
PMCID: PMC4742081

Genes

TMPRSS6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Effect of Erythropoietin, Iron Deficiency and Iron Overload on Liver Matriptase-2 (TMPRSS6) Protein Content in Mice and Rats.PMID 26845567Read ↗

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