Article
A TRPM7 mutation linked to familial trigeminal neuralgia: Omega current and hyperexcitability of trigeminal ganglion neurons.
Proceedings of the National Academy of Sciences of the United States of America - 20 Sept 2022
Gualdani Roberta, Gailly Philippe, Yuan Jun-Hui, Yerna Xavier, Di Stefano Giulia, Truini Andrea, Cruccu Giorgio, Dib-Hajj Sulayman D, Waxman Stephen G
Abstract excerpt
Trigeminal neuralgia (TN) is a unique pain disorder characterized by intense paroxysmal facial pain within areas innervated by the trigeminal nerve. Although most cases of TN are sporadic, familial clusters of TN suggest that genetic factors may contribute to this disorder. Whole-exome sequencing...
Topics
- Alanine
- Humans
- Male
- Mutation
- Neurons
- Protein Serine-Threonine Kinases
- TRPM Cation Channels
- Trigeminal Ganglion
- Trigeminal Neuralgia