Article
Reconstruction of viral population structure from next-generation sequencing data using multicommodity flows.
BMC bioinformatics - 1 Jan 2013
Skums Pavel, Mancuso Nicholas, Artyomenko Alexander, Tork Bassam, Mandoiu Ion, Khudyakov Yury, Zelikovsky Alex
Abstract excerpt
BACKGROUND: Highly mutable RNA viruses exist in infected hosts as heterogeneous populations of genetically close variants known as quasispecies. Next-generation sequencing (NGS) allows for analysing a large number of viral sequences from infected patients, presenting a novel opportunity for studying the structure of a viral population and understanding virus evolution, drug resistance and immune escape. Accurate...
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