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Article

Structural basis of Vps33A recruitment to the human HOPS complex by Vps16.

Proceedings of the National Academy of Sciences of the United States of America - 13 Aug 2013

Graham Stephen C, Wartosch Lena, Gray Sally R, Scourfield Edward J, Deane Janet E, Luzio J Paul, Owen David J

Abstract excerpt

The multisubunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for late endosome-lysosome and autophagosome-lysosome fusion in mammals. We have determined the crystal structure of the human HOPS subunit Vps33A, confirming its identity as a Sec1/Munc18...

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Identifiers

PMID: 23901104
DOI: 10.1073/pnas.1307074110
PMCID: PMC3746937

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23901104-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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