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Article

Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling.

Developmental biology - 1 Oct 2013

Lu Karol, Reddy Raghava, Berika Mohamed, Warburton David, El-Hashash Ahmed H K

Abstract excerpt

The Eya1 gene encodes a transcriptional co-activator that acts with Six1 to control the development of different organs. However, Six1-Eya1 interactions and functional roles in mesenchymal cell proliferation and differentiation as well as alveolarization during the saccular stage of lung development are still unknown. Herein, we provide the first evidence that Six1 and Eya1 act together to regulate mesenchymal...

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Source

Identifiers

PMID: 23895934
DOI: 10.1016/j.ydbio.2013.07.019

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SHH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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