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Article

Epithelial inactivation of Yy1 abrogates lung branching morphogenesis.

Development (Cambridge, England) - 1 Sept 2015

Boucherat Olivier, Landry-Truchon Kim, Bérubé-Simard Félix-Antoine, Houde Nicolas, Beuret Laurent, Lezmi Guillaume, Foulkes William D, Delacourt Christophe, Charron Jean, Jeannotte Lucie

Abstract excerpt

Yin Yang 1 (YY1) is a multifunctional zinc-finger-containing transcription factor that plays crucial roles in numerous biological processes by selectively activating or repressing transcription, depending upon promoter contextual differences and specific protein interactions. In mice, Yy1 null mutants die early in gestation whereas Yy1 hypomorphs die at birth from lung defects. We studied how the...

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Source

Identifiers

PMID: 26329601
DOI: 10.1242/dev.120469

Genes

DICER1
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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