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Article

Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer.

Breast cancer research and treatment - 1 Apr 2010

Board Ruth E, Wardley Andrew M, Dixon J Michael, Armstrong Anne C, Howell Sacha, Renshaw Lorna, Donald Emma, Greystoke Alastair, Ranson Malcolm, Hughes Andrew, Dive Caroline

Abstract excerpt

Somatic mutations in PIK3CA (encoding a class I phosphoinositide 3 kinase (PI3K) subunit) modulate PI3K signalling to influence tumour behaviour and occur in up to 40% of breast cancers. Inhibitors of PI3K signalling are entering clinical trials, but the impact of PIKC3A mutation on tumour respon...

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Identifiers

PMID: 20107891
DOI: 10.1007/s10549-010-0747-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20107891-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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