Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer.

Breast cancer research and treatment - 1 Apr 2010

Board Ruth E, Wardley Andrew M, Dixon J Michael, Armstrong Anne C, Howell Sacha, Renshaw Lorna, Donald Emma, Greystoke Alastair, Ranson Malcolm, Hughes Andrew, Dive Caroline

Abstract excerpt

Somatic mutations in PIK3CA (encoding a class I phosphoinositide 3 kinase (PI3K) subunit) modulate PI3K signalling to influence tumour behaviour and occur in up to 40% of breast cancers. Inhibitors of PI3K signalling are entering clinical trials, but the impact of PIKC3A mutation on tumour response has yet to be clarified. This study investigated the potential utility of circulating free DNA (cfDNA) as a source...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chronic Lymphocytic Leukemia Research

Share to Class I Phosphatidylinositol 3-Kinases

Share to DNA Mutational Analysis

Share to Mutation

Share to Phosphatidylinositol 3-Kinases

Source

Identifiers

PMID: 20107891
DOI: 10.1007/s10549-010-0747-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer.PMID 20107891Read ↗

Diagnostic Accuracy of PIK3CA Mutation Detection by Circulating Free DNA in Breast Cancer: A Meta-Analysis of Diagnostic Test Accuracy.Semantic proximity Read ↗

PIK3CA mutations in plasma circulating tumor DNA predict survival and treatment outcomes in patients with advanced cancers.Semantic proximity Read ↗

Identification of E545k mutation in plasma from a PIK3CA wild-type metastatic breast cancer patient by array-based digital polymerase chain reaction: Circulating-free DNA a powerful tool for biomarker testing in advance disease.Semantic proximity Read ↗

Detection of TP53 and PIK3CA Mutations in Circulating Tumor DNA Using Next-Generation Sequencing in the Screening Process for Early Breast Cancer DiagnosisSemantic proximity Read ↗

PIK 3 CA hotspot mutations in circulating tumor cells and paired circulating tumor DNA in breast cancer: a direct comparison studySemantic proximity Read ↗

Analysing the mutational status of PIK3CA in circulating tumor cells from metastatic breast cancer patients.Semantic proximity Read ↗

Circulating PIK3CA mutation detection at diagnosis in non-metastatic inflammatory breast cancer patients.Semantic proximity Read ↗

Cell-free DNA as a molecular tool for monitoring disease progression and response to therapy in breast cancer patients.Semantic proximity Read ↗

Detection of cancer DNA in plasma of patients with early-stage breast cancer.Semantic proximity Read ↗

Development of multiplex digital PCR assays for the detection of PIK3CA mutations in the plasma of metastatic breast cancer patients.Semantic proximity Read ↗

High mutation burden of circulating cell-free DNA in early-stage breast cancer patients is associated with a poor relapse-free survival.Semantic proximity Read ↗

Prognostic role of PIK3CA mutations of cell-free DNA in early-stage triple negative breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.