Article
The p53 miRNA interactome and its potential role in the cancer clinic.
Epigenomics - 1 Aug 2013
Krell Jonathan, Frampton Adam E, Colombo Teresa, Gall Tamara M H, De Giorgio Alex, Harding Victoria, Stebbing Justin, Castellano Leandro
Abstract excerpt
p53 is one of the most frequently mutated tumor suppressors. It regulates protein-coding genes and noncoding RNAs involved in many cellular processes, functioning predominantly at the transcriptional level but also through nontranscriptional processes. miRNAs have recently been identified as key mediators of the p53 stress-response pathway. p53 regulates miRNA transcription and processing, and miRNAs regulate p53...
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