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Article

MicroRNA-Mutant P53 Crosstalk in Chemoresistance: A Hint to Monitor Therapy Outcome.

MicroRNA (Shariqah, United Arab Emirates) - 1 Jan 2020

Speciale Andrea, Monti Paola, Fronza Gilberto, Izzotti Alberto, Menichini Paola

Abstract excerpt

The chemoresistance of cancer cells is a multifactorial mechanism in which de-regulated apoptotic pathways, the oxidative response and cancer cell migration play a crucial role. A key player in the control of such pathways is the tumor suppressor gene TP53, also defined as the "guardian of the genome", encoding the P53 tetrameric transcription factor. P53, following cell injuries, can activate the transcription...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33297928
DOI: 10.2174/2211536609666201209151659

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