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Article

Role for the epidermal growth factor receptor in chemotherapy-induced alopecia.

PloS one - 1 Jan 2013

Bichsel Kyle J, Gogia Navdeep, Malouff Timothy, Pena Zachary, Forney Eric, Hammiller Brianna, Watson Patrice, Hansen Laura A

Abstract excerpt

Treatment of cancer patients with chemotherapeutics like cyclophosphamide often causes alopecia as a result of premature and aberrant catagen. Because the epidermal growth factor receptor (EGFR) signals anagen hair follicles to enter catagen, we hypothesized that EGFR signaling may be involved in cyclophosphamide-induced alopecia. To test this hypothesis, skin-targeted Egfr mutant mice were generated by crossing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23894460
DOI: 10.1371/journal.pone.0069368
PMCID: PMC3716704

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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