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Article

EGFR inhibitors switch keratinocytes from a proliferative to a differentiative phenotype affecting epidermal development and barrier function.

BMC cancer - 5 Jan 2021

Joly-Tonetti Nicolas, Ondet Thomas, Monshouwer Mario, Stamatas Georgios N

Abstract excerpt

BACKGROUND: Cutaneous adverse drug reactions (CADR) associated with oncology therapy involve 45-100% of patients receiving kinase inhibitors. Such adverse reactions may include skin inflammation, infection, pruritus and dryness, symptoms that can significantly affect the patient's quality of life. To prevent severe skin damages dose adjustment or drug discontinuation is often required, interfering with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33402117
DOI: 10.1186/s12885-020-07685-5
PMCID: PMC7786949

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