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Article

Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development.

Molecular biology of the cell - 1 Nov 2018

Tripurani Swamy K, Wang Yan, Fan Ying-Xin, Rahimi Massod, Wong Lily, Lee Min-Hyung, Starost Matthew F, Rubin Jeffrey S, Johnson Gibbes R

Abstract excerpt

Mice that lack the epidermal growth factor receptor (EGFR) fail to develop a hair coat, but the mechanism responsible for this deficit is not completely understood. Here, we show that EGFR plays a critical role to attenuate wingless-type MMTV integration site family member (Wnt)/β-catenin signaling during postnatal hair follicle development. Genetic ablation of EGFR in mice resulted in increased mitotic activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30188763
DOI: 10.1091/mbc.E18-08-0488
PMCID: PMC6249831

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