Article
In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling.
Cancer research - 1 Oct 2006
Dumaz Nicolas, Hayward Robert, Martin Jan, Ogilvie Lesley, Hedley Douglas, Curtin John A, Bastian Boris C, Springer Caroline, Marais Richard
Abstract excerpt
Melanocytes require the RAS/RAF/MEK/ERK and the cyclic AMP (cAMP) signaling pathways to maintain the fine balance between proliferation and differentiation. We have investigated how cross-talk between these pathways affects melanoma progression. We show that cAMP suppresses CRAF activity in melanocytes and that this is essential to suppress the oncogenic potential of CRAF in these cells. As a consequence, BRAF...
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