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Article

Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease.

Nature genetics - 1 Sept 2013

Ma Ming, Tian Xin, Igarashi Peter, Pazour Gregory J, Somlo Stefan

Abstract excerpt

Kidney cysts occur following inactivation of polycystins in otherwise intact cilia or following complete removal of cilia by inactivation of intraflagellar transport-related proteins. We investigated the mechanisms of cyst formation in these two distinct processes by combining conditional inactivation of polycystins with concomitant ablation of cilia in developing and adult kidney and liver. We found that loss of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23892607
DOI: 10.1038/ng.2715
PMCID: PMC3758452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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