The Mcu1 mitochondrial protein coordinates TCA cycle enzymes to modulate phenotypic switching and commensalism in Candida albicans.

Abstract excerpt

Candida albicans is a common resident of humans that colonizes multiple sites in the human body, such as the gut, in healthy individuals. In immunocompromised hosts, however, it can switch to a pathogenic state and cause infections. The molecular mechanisms underlying this commensal-pathogenic transition have not been fully elucidated. Here, we demonstrate that the mitochondrial protein Mcu1, which is required...

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