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Article

Phenotypic assays for β-amyloid in mouse embryonic stem cell-derived neurons.

Chemistry & biology - 25 Jul 2013

McIntire Laura Beth J, Landman Natalie, Kang Min Suk, Finan Gina M, Hwang Jeremy C, Moore Ann Z, Park Lydia S, Lin Chyuan-Sheng, Kim Tae-Wan

Abstract excerpt

Given the complex nature of Alzheimer's disease (AD), a cell-based model that recapitulates the physiological properties of the target neuronal population would be extremely valuable for discovering improved drug candidates and chemical probes to uncover disease mechanisms. We established phenotypic neuronal assays for the biogenesis and synaptic action of amyloid β peptide (Aβ) based on embryonic stem...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23890013
DOI: 10.1016/j.chembiol.2013.06.005
PMCID: PMC3780781

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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