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Article

New insights into the functional role of the rheumatoid arthritis shared epitope

21 Mar 2011

Abstract excerpt

The shared epitope (SE) - an HLA-DRB1-encoded 5-amino acid sequence motif carried by the vast majority of rheumatoid arthritis (RA) patients - is a risk factor for severe disease. The mechanistic basis of RA-SE association is unknown. This group has previously demonstrated that the SE acts as a signal transduction ligand that activates nitric oxide and reactive oxygen species production. SE-activated signaling...

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PMID: 21420962
DOI: 10.1016/j.febslet.2011.03.035

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