Article
Site-specific replacement of amino acid residues within the CD binding loop of rat oncomodulin.
The Journal of biological chemistry - 25 Aug 1990
Palmisano W A, Treviño C L, Henzl M T
Abstract excerpt
Relative to the same site in oncomodulin, the CD ion-binding domain of rat parvalbumin exhibits much greater affinity for Ca2+ and Mg2+. As part of an effort to understand the structural basis for these differences, site-specific variants of oncomodulin have been prepared in which the amino acid...
Topics
- Animals
- Binding Sites
- Calcium
- Calcium-Binding Proteins
- Cations, Divalent
- Electrophoresis, Polyacrylamide Gel
- Genetic Variation
- Hydrogen-Ion Concentration
- Luminescent Measurements
- Magnesium
- Neoplasm Proteins
- Protein Conformation