Article
Leucine 85 is an important determinant of divalent ion affinity in rat beta-parvalbumin (Oncomodulin).
Biochemistry - 23 Dec 2008
Henzl Michael T, Davis Meredith E, Tan Anmin
Abstract excerpt
Despite 69% sequence identity with chicken parvalbumin 3 (CPV3), rat beta-parvalbumin (beta-PV) exhibits a substantially lower Ca(2+) affinity (DeltaDeltaG degrees ' = 2.0 kcal/mol). This difference largely reflects the disparate behavior of the respective CD sites. Replacement of the rat beta-PV codon with the CPV3 codon at positions 49, 50, and 57-60 produces virtual sequence identity with the CPV3 CD site....
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