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Article

Remodeling of the AB site of rat parvalbumin and oncomodulin into a canonical EF-hand.

European journal of biochemistry - 1 Sept 1999

Cox J A, Durussel I, Scott D J, Berchtold M W

Abstract excerpt

Parvalbumin (PV) and the homologous protein oncomodulin (OM) contain three EF-hand motifs, but the first site (AB) cannot bind Ca2+. Here we aimed to recreate the putative ancestral proteins [D19-28E]PV and [D19-28E]OM by replacing the 10-residue-long nonfunctional loop in the AB site by a 12-residue canonical loop. To create an optical conformational probe we also expressed the homologs with a F102W replacement....

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Source

Identifiers

PMID: 10491125
DOI: 10.1046/j.1432-1327.1999.00650.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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