Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.

doi:10.1182/blood-2013-01-476473

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Article

Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.

Blood - 5 Sept 2013

Opatz Sabrina, Polzer Harald, Herold Tobias, Konstandin Nikola P, Ksienzyk Bianka, Zellmeier Evelyn, Vosberg Sebastian, Graf Alexander, Krebs Stefan, Blum Helmut, Hopfner Karl-Peter, Kakadia Purvi M, Schneider Stephanie, Dufour Annika, Braess Jan, Sauerland Maria Cristina, Berdel Wolfgang E, Büchner Thomas, Woermann Bernhard J, Hiddemann Wolfgang, Spiekermann Karsten, Bohlander Stefan K, Greif Philipp A

Abstract excerpt

The t(8;21) and inv(16)/t(16;16) rearrangements affecting the core-binding factors RUNX1 and CBFB, respectively, are found in 15% to 20% of adult de novo acute myeloid leukemia (AML) cases and are associated with a favorable prognosis. Since the expression of the fusion genes CBFB/MYH11 or RUNX1/RUNX1T1 alone is not sufficient to cause leukemia, we performed exome sequencing of an AML sample with an inv(16) to...

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Identifiers

PMID: 23878140
DOI: 10.1182/blood-2013-01-476473

Genes

FLT3
CBFB
MYH11
RUNX1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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