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Article

K‑ras gene mutation as a predictor of cancer cell responsiveness to metformin.

Molecular medicine reports - 1 Sept 2013

Ma Yu, Guo Fu-Chun, Wang Wei, Shi Hua-Shan, Li Dan, Wang Yong-Sheng

Abstract excerpt

An increasing number of studies support the use of metformin, a common antidiabetic drug, as a novel anticancer therapeutic. However, its mechanism of action has yet to be identified. In the current study, metformin was observed to effectively inhibit the growth of the K-ras mutant but not wild-type tumors in vivo. The antitumor effects of metformin were mediated by the induction of apoptosis and inhibition of...

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Identifiers

PMID: 23877793
DOI: 10.3892/mmr.2013.1596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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