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Patient- and Cell Type-Specific Heterogeneity of Metformin Response.

Basic & clinical pharmacology & toxicology - 1 Feb 2018

Asiedu Michael K, Barron Matthew, Aubry Marie Christine, Wigle Dennis A

Abstract excerpt

Most FDA-approved drugs are not equally effective in all patients, suggesting that identification of biomarkers to predict responders to a chemoprevention agent will be needed to stratify patients and achieve maximum benefit. The goal of this study was to investigate both patient-specific and cell context-specific heterogeneity of metformin response, using fibroblast cell lines and induced pluripotent stem cells...

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Identifiers

PMID: 28862803
DOI: 10.1111/bcpt.12898

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