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Article

Role of p53 Family Proteins in Metformin Anti-Cancer Activities

1 Jan 2019

Abstract excerpt

Metformin has been used as therapy for type 2 diabetes for many years. Clinical and basic evidence as indicated that metformin has anti-cancer activities. It has been well-established that metformin activates AMP-activated protein kinase (AMPK), which in turn regulates energy homeostasis. However, the mechanistic aspects of metformin anti-cancer activity remain elusive. p53 family proteins, including p53, p63 and...

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PMID: 31258748
DOI: 10.7150/jca.30659

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