Article
Reversion of the ErbB malignant phenotype and the DNA damage response.
Experimental and molecular pathology - 1 Dec 2012
Runkle E Aaron, Zhang Hongtao, Cai Zheng, Zhu Zhiqiang, Karger Barry L, Wu Shiaw-Lin, O'Rourke Donald M, Zhou Zhaocai, Wang Qiang, Greene Mark I
Abstract excerpt
The ErbB or HER family is a group of membrane bound tyrosine kinase receptors that initiate signal transduction cascades, which are critical to a wide range of biological processes. When over-expressed or mutated, members of this kinase family form homomeric or heteromeric kinase assemblies that are involved in certain human malignancies. Targeted therapy evolved from studies showing that monoclonal antibodies to...
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