Article
Functions of TAp63 and p53 in restraining the development of metastatic cancer.
Oncogene - 19 Jun 2014
Tan E H, Morton J P, Timpson P, Tucci P, Melino G, Flores E R, Sansom O J, Vousden K H, Muller P A J
Abstract excerpt
Many tumours harbour mutations in the p53 tumour-suppressor gene that result in the expression of a mutant p53 protein. This mutant p53 protein has, in most cases, lost wild-type transcriptional activity and can also acquire novel functions in promoting invasion and metastasis. One of the mechanisms underlying these novel functions involves the ability of the mutant p53 to interfere with other transcription...
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