Article
Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice.
Neuropharmacology - 1 Dec 2013
Bortolato Marco, Godar Sean C, Tambaro Simone, Li Felix G, Devoto Paola, Coba Marcelo P, Chen Kevin, Shih Jean C
Abstract excerpt
Monoamine oxidase (MAO) A, the major enzyme catalyzing the oxidative degradation of serotonin (5-hydroxytryptamine, 5-HT), plays a key role in emotional regulation. In humans and mice, MAO-A deficiency results in high 5-HT levels, antisocial, aggressive, and perseverative behaviors. We previously showed that the elevation in brain 5-HT levels in MAO-A knockout (KO) mice is particularly marked during the first two...
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