Article
Tumour antigen targeted monoclonal antibodies incorporating a novel multimerisation domain significantly enhance antibody dependent cellular cytotoxicity against colon cancer.
European journal of cancer (Oxford, England : 1990) - 1 Oct 2013
Jain Ajay, Poonia Bhawna, So Edward C, Vyzasatya Ravi, Burch Erin E, Olsen Henrik S, Mérigeon Emmanuel Y, Block David S, Zhang Xiaoyu, Schulze Dan H, Hanna Nader N, Twadell William S, Yfantis Harris G, Chan Siaw L, Cai Ling, Strome Scott E
Abstract excerpt
Tumour antigen targeted antibodies (mAbs) can induce natural killer (NK) cells to kill tumours through antibody dependent cellular cytotoxicity (ADCC) upon engagement of NK cell expressed FcγRIIIa. FcγRIIIa polymorphisms partially dictate the potency of the ADCC response. The high affinity FcγRIIIa-158-valine (V) polymorphism is associated with more potent ADCC response than the low affinity...
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