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Article

Ex vivo antibody-dependent cellular cytotoxicity inducibility predicts efficacy of cetuximab.

Cancer immunology research - 1 May 2015

Taylor Rodney J, Saloura Vassiliki, Jain Ajay, Goloubeva Olga, Wong Stuart, Kronsberg Shari, Nagilla Madhavi, Silpino Lorna, de Souza Jonas, Seiwert Tanguy, Vokes Everett, Villaflor Victoria, Cohen Ezra E W

Abstract excerpt

We conducted in vitro studies and a clinical trial for patients with squamous cell carcinoma of the head and neck (SCCHN) to study the relationship between FcγRIIIa polymorphisms and antibody-dependent cellular cytotoxicity (ADCC). In vitro, FcγRIIIa genotype was correlated with ADCC and innate cytotoxicity using natural killer (NK) cells harvested from healthy donors. In the phase II study, patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25769300
DOI: 10.1158/2326-6066.CIR-14-0188
PMCID: PMC4681575

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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