Cytotoxic drugs up-regulate epidermal growth factor receptor (EGFR) expression in colon cancer cells and enhance their susceptibility to EGFR-targeted antibody-dependent cell-mediated-cytotoxicity (ADCC).

doi:10.1016/j.ejca.2010.03.005

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Article

Cytotoxic drugs up-regulate epidermal growth factor receptor (EGFR) expression in colon cancer cells and enhance their susceptibility to EGFR-targeted antibody-dependent cell-mediated-cytotoxicity (ADCC).

European journal of cancer (Oxford, England : 1990) - 1 Jun 2010

Correale Pierpaolo, Marra Monica, Remondo Cinzia, Migali Cristina, Misso Gabriella, Arcuri Felice Paolo, Del Vecchio Maria Teresa, Carducci Antonietta, Loiacono Lucia, Tassone Pierfrancesco, Abbruzzese Alberto, Tagliaferri Pierosandro, Caraglia Michele

Abstract excerpt

Cetuximab is a human-murine chimeric IgG1 monoclonal antibody to epidermal growth factor-receptor (EGFR) which exerts synergistic antitumour interactions with several cytotoxic drugs. Therefore, it is presently recommended in combination with chemotherapy in the treatment of colon, head and neck and non-small cell lung cancer. Cetuximab has been designed to inhibit EGFR signalling; however, preclinical evidence...

Topics

Antibodies, Monoclonal
Antibodies, Monoclonal, Humanized
Antibody-Dependent Cell Cytotoxicity
Antineoplastic Agents
Blotting, Western
Camptothecin
Cell Line, Tumor
Cetuximab

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Colonic Neoplasms

Deoxycytidine

Drug Synergism

ErbB Receptors

Fluorouracil

Genes, ras

Humans

Irinotecan

Killer Cells, Lymphokine-Activated

Mutation

Source

Open in PubMed

Identifiers

PMID: 20399639
DOI: 10.1016/j.ejca.2010.03.005

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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